Dr Jayne Dennis
Lecturer in Biomedical Science, Director of Student Experience
Email: email@example.comTelephone: +44 (0)20 7882 5018Room Number: Room 3.21, Fogg Building
My teaching centres on human genetics, specifically:
- The genetics of health and disease, especially cancer,
- Human genomics,
- Precision medicine, and
- Basic bioinformatics.
I am a tutor for all three years of undergraduate students (on modules BIO191, BIO193, BIO209 and BIO309) and I mentor project skills students. In addition, I am an academic advisor and programme tutor.
I am the Director of Student Experience in SBCS, responsible for the holistic overview of student life including academic, social and support issues. Consequently I chair the Student-Staff Liaison Committee (SSLC), sit on the Teaching & Learning Committee (TLC), and participate in the Teaching Interest Group and Educational Research (TIGER) committee.
I study part-time for an MA in the psychology of education at the world-leading Institute of Education, which is now part of University College London.
In 2014-2016 I was responsible for the undergraduate Ciência sem Fronteiras scholarship programme within SBCS. My responsibilities included: admissions, programme specification, pastoral care, coordinating research projects, and organising teaching modules created specifically to meet the academic needs of this cohort of international students.
Previously I worked at St George’s, University of London (SGUL), where I obtained my Postgraduate Certificate in Biomedical & Healthcare Education. I continue teaching at SGUL as a visiting lecturer on three modules: Human Medical Genetics, Personalised Medicine and Cancer Biology.
My research interests focus on precision medicine - the use of molecular and genetic information in the clinical management of disease, especially cancer. My PhD (University of Glasgow) investigated gene expression profiles in the classification of primary cancers. This work formed the basis of a classification algorithm for Carcinoma of Unknown Primary which is now integral to a Cancer Research UK sponsored clinical trial (CUP-ONE, CRUK/08/006).
Following my post-doc at Imperial College at Hammersmith Hospital I held senior positions in two genomics facilities.
Latham Birt SH, Botham KM, Dennis JL & Wheeler-Jones CP (2016) Effects of model chylomicron remnants on gene expression in human aortic endothelial cells (HAEC). Submitted.
Liu WM, Scott KA, Dennis JL Kaminska E, Levett AJ & Dalgleish AG (2016) Naltrexone at low doses upregulates a unique gene expression not seen with normal doses; implications for its use in cancer therapy. Int J Oncol. 49(2): 793-802
Scott, KA, Dennis JL, Dalgleish AG & Liu WM (2015) Inhibiting heat shock proteins can potentiate the cytotoxic effect of cannabidiol in human glioma cells. Anticancer Res 35(11): 5827-37
Oien KA & Dennis JL (2012) Diagnostic work-up of carcinoma of unknown primary: from immunohistochemistry to molecular profiling. Ann Oncol 23 suppl 10: x271-277
Le Bihan M, Bigot A, Skov Jensen S, Dennis JL, Rogowska-Wrzesinska A, Lainé J, Gache V, Furlong D, Nørregaard Jensen O, Voit T, Mouly V, Coulton G, & Butler-Browne G. (2012) In- depth analysis of the secretome identifies three major independent secretory pathways in differentiating human myoblasts. J Proteomics 77:344-356
Liu WM, Dennis JL, Gravett AM, Chanthirakumar C, Kaminska E, Coulton G, Fowler DW, Bodman-Smith M, Dalgleish AG. (2012) Supernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis. Br J Cancer 106(5):896-903.
Liu WM, Dennis JL, Fowler DW, Dalgleish AG. (2012) The gene expression profile of un-stimulated dendritic cells can be used as a predictor of function. Int J Cancer. 130(4):979-90
Pathan N, Franklin JL, Eleftherohorinou H, Wright VJ, Hemingway CA, Waddell SJ, Griffiths M, Dennis JL, Relman DA, Harding SE, Levin M. (2011) Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase. Crit Care Med. 39(7):1692-711
Cullingford TE, Markou T, Fuller SJ, Giraldo A, Pikkarainen S, Zoumpoulidou G, Alsafi A, Ekere C, Kemp TJ, Dennis JL, Game L, Sugden PF, and Clerk A. (2008) Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes. Genome Biology 9:R32
Tomlinson C, Thimma M, Alexandrakis S, Castillo T, Dennis JL, Brooks A, Bradley T, Turnbull C, Blaveri E, Barton G, Chiba N, Maratou K, Soutter P, Aitman T & Game L. (2008) MiMiR: an integrated platform for microarray data sharing, mining and analysis. BMC Bioinformatics 9:379
Oien KA, Dennis JL, Evans TRJ (2007) Metastatic adenocarcinoma of unknown origin. In Progress in Pathology 7 (editors N. Kirkham & N. Shepherd), Cambridge University Press, pp 135-162
Dennis JL & Oien KA. (2005) Hunting the primary: novel strategies for defining the origin of tumours J Pathol 205:236-47
Dennis JL, Hvidsten TR, Wit EC, Komorowski J, Bell AK, Downie I, Mooney J, Verbeke C, Bellamy C, Keith WN & Oien KA. (2005) Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm. Clin Cancer Res 11:3766-72
Dennis JL, Westra J, Bell A, Montgomery K & Oien K. (2003) The type and quality of paraffin wax is important when constructing tissue microarrays (TMAs) Mol Pathol 56:306
Dennis JL, Vass JK, Wit EC, Keith WN & Oien KA. (2002) Identification from public data of molecular markers of adenocarcinoma characteristic of the site of origin Cancer Res. 62:5999-6005
Griffiths RA, Schley L, Sharp PE, Dennis JL & Román A (1998) Behavioural responses of Mallorcan midwife toad tadpoles to natural and unnatural snake predators. Anim Behav 55(1): 2-7-14