IUBMB Enzyme Nomenclature


Accepted name: medicarpin synthase

Reaction: 7,2'-dihydroxy-4'-methoxyisoflavanol = (–)-medicarpin + H2O

For diagram of reaction click here.

Glossary: (–)-medicarpin = (6aR,11aR)-9-methoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol

Other name(s): medicarpan synthase; 7,2'-dihydroxy-4'-methoxyisoflavanol; DMI dehydratase; DMID

Systematic name: 7,2'-dihydroxy-4'-methoxyisoflavanol hydro-lyase [(–)-medicarpin-forming]

Comments: Isolated from the plant Medicago sativa (alfalfa). Catalyses the final step in the biosynthesis of medicarpin, the main pterocarpan phytoalexin in alfalfa.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Guo, L., Dixon, R.A. and Paiva, N.L. The 'pterocarpan synthase' of alfalfa: association and co-induction of vestitone reductase and 7,2'-dihydroxy-4'-methoxy-isoflavanol (DMI) dehydratase, the two final enzymes in medicarpin biosynthesis. FEBS Lett 356 (1994) 221-225. [PMID: 7805842]

2. Guo, L., Dixon, R.A. and Paiva, N.L. Conversion of vestitone to medicarpin in alfalfa (Medicago sativa L.) is catalyzed by two independent enzymes. Identification, purification, and characterization of vestitone reductase and 7,2'-dihydroxy-4'-methoxyisoflavanol dehydratase. J. Biol. Chem. 269 (1994) 22372-22378. [PMID: 8071365]

[EC created 2013]

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