Semester 1: Weeks 2, 4, 6, 10: Friday 9 am - 10 am
Semester 1: Weeks 3, 8, 10: Friday 2 pm - 5 pm
Contact: Dr Sadani Cooray Overlap: None Prerequisite: BMD115 or BIO111
This module will cover the main drug targets including receptors, enzymes and transporters and molecular therapeutic drug targets such as DNA, rRNA and mRNA. Lecture content will include, topics such as receptor theory, GPCR structure and function, nuclear receptor structure and function, ligand-gated ion channels, receptor tyrosine kinases, signalling pathways including Jak/STAT pathway, an overview of developmental signalling, hedgehog pathway, Wnt pathway, TGF beta/BMP, Notch and FGF pathways and crosstalk between these pathways. Lectures will be followed by interactive sessions in specialised areas of the subject given by experts in their field. In addition to formal lectures, the course will provide tutorials and seminars with opportunities to critically-evaluate research papers and reinforce the lectures.