- Semester 1: Monday 9 am - 11 am
Contact: Prof Tony Vlcek
Prerequisites: Contemporary Inorganic Chemistry (CHE512). This module seeks to provide a coherent introduction into the roles that metals play in biological and medicinal systems. The first six lectures of the module focus on electron transfer and will include an introduction to basic terms (redox potential and its tuning in biological systems, excited-state electron transfer) and elements of the Marcus theory, followed by a discussion of electron transfer processes in biology, including light-energy harvesting and conversion in photosynthetic reaction centre, long-range electron transfer in metalloproteins, DNA and molecular wires. Application in molecular devices will be discussed as well. Molecular redox chemistry and electrochemistry including redox catalysis is surveyed.The next set of lectures detail the role that metal plays in a range of biological systems and in medical applications. Initially the focus will be on electron transport in naturally occurring systems such as in the oxygen evolving centre within PS2 of the photosynthetic apparatus, nitrogenase enzymes and the role of iron-porphyrin complexes in biological electron transfer. There will then follow a discussion of the roles metals play as Lewis acids in a range of biological systems covering metalloenzymes such as carbonic anhydrase, liver alcohol dehrdrogenase and nickel urease. The final lectures in this part of the module will focus on the roles metal play in medicine eg anti-ageing drugs, anti-cancer drugs and in imaging agents.The final four lectures of the module will begin with an introduction to the important area of biomaterials, which will then be followed by an overview of selected topics from the areas of metallic biomaterials, ceramic biomaterials and bioglasses. The final lecture will consider implant/host interactions and the factors affecting long-term performance of a biomaterial.
Connected course(s): UDF DATA
Assessment: 90.0% Examination, 10.0% Coursework