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Shaima Hashem

Shaima

PhD student

Email: s.hashem@qmul.ac.uk

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Project title: In silico study of mechanisms of functional modulation in cardiac muscle proteins

Summary: My project involves the study of the mechanism of action of sarcomeric modulators (e.g. Omecamtiv Mecarbil) and their effects on the dynamics and the allostery of cardiac proteins, both in their wild type and mutated form. I will use a variety of computational techniques, including basic and advanced molecular dynamics, comparative modelling, fragment based design and structural bioinformatics tools.

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