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Dr Lesley Howell

Lecturer in Pharmaceutical/Medicinal Chemistry

Email: l.howell@qmul.ac.uk
Telephone: +44 (0)20 7882 6625
Room Number: Room G.03, Joseph Priestley building

Teaching

  • Module organizer for Pharmaceutical Chemistry (CHE206A & B)
  • Teach on Foundations of Practical Chemistry (CHE101)
  • Teach on Advanced Pharmaceutical Chemistry (CHE306)
  • Teach on Advanced Practical Chemistry (CHE301)

Research

Research Interests:

Research in our group is focused on both protein-protein interactions (PPIs)  and protein-DNA interactions and harnessing their potential as drug targets. We do this by using both solution and solid phase synthesis to generate compounds/peptides capable on interacting with these targets. We take inspiration from natural products when designing compounds but also design new molecules from scratch. Within this theme we have several projects:

  1. Reactivation of the Bcl-2 mediated apoptosis pathway as a way to treat cancer
  2. Development of new approaches/technology to target PPIs
  3. Disruption of G-protein coupled receptor (GPCR) heteromers as novel drug targets
  4. Identification and synthesis of ligands for orphan GPCRs

Research department:

Public Engagement

I am a STEM ambassador and CHEMNet ambassador through the Royal Society of Chemistry.

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