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School of Biological and Chemical Sciences

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Professor Gavin Vinson

Gavin

Email: g.p.vinson@qmul.ac.uk
Telephone: +44 (0)20 7882 6330

Research

Research Interests:

Mechanisms of secretion and actions of steroid hormones, especially in regard to the adrenal cortex, mineralocorticoid and glucocorticoid function; hypertension and the cardiovascular system; reproduction; G-protein coupled receptor function, especially angiotensin II; and cancer; drugs that interact with all of these functions.

Publications

  • G. P. Vinson, B. J. Whitehouse, and J. P. Hinson. (2007). Adrenal cortex. In G. Fink, ed. Encyclopedia of Stress, 2nd ed., Academic Press, Oxford. Vol 1. pp 38-51.
  • G. P. Vinson (2007). Angiotensin II, corticosteroids, type II diabetes and the metabolic syndrome. Medical hypotheses, 68, 1200-1207.
  • G. P. Pilipuk, G. P. Vinson, C. G. Sanchez, and M. D. Galigniana. (2007). Evidence for NL1-independent nuclear translocation of the mineralocorticoid receptor. Biochemistry, 46, 1389-139.
  • J.R. Puddefoot, S. Barker, G.P. Vinson. (2006). Trilostane in advanced breast cancer. Expert opinion in pharmacotherapeutics, 7, 2413-2419.
  • D. Pignatelli, F. Xiao, A. Gouveia, J. G. Ferreira, and G. P. Vinson. (2006). Adrenarche in the rat. J. Endocr., 191, 301-308.
  • J. R. Puddefoot, U. K. I. Udeozo, S. Barker, and G. P. Vinson. (2006). The role of angiotensin II in the regulation of breast cancer cell adhesion and invasion. Endocrine related cancer, 13, 895-903.
  • S. D. M. Malouitre, S. Barker, J. R. Puddefoot, J. Jalili, H. R. Glover, and G. P. Vinson. (2006). Regulation of hepatic steroid receptors and enzymes by the 3b-hydroxysteroid dehydrogenase inhibitor trilostane. J Steroid Biochem Mol Biol. 101, 97-105. 
  • M. Tahmasebi, S. Barker, J. R. Puddefoot, and G. P. Vinson. (2006). Localisation of renin-angiotensin system (RAS) components in breast. Br J Cancer, 95, 67-74.
  • S. Barker, S. D. Malouitre, H. R. Glover, J. R. Puddefoot, and G. P. Vinson. (2006). Comparison of effects of 4-hydroxy tamoxifen and trilostane on oestrogen-regulated gene expression in MCF-7 cells: Up-regulation of oestrogen receptor beta. J Steroid Biochem Mol Biol. 100, 141-151.
  • L. Min, N. V. Strushkevich, I. N. Harnastai, H. Iwamoto, A. A. Gilep, H. Takemori, S. A. Usanov, Y. Nonaka, H. Hori, G. P. Vinson, and M. Okamoto. (2005). Molecular identification of adrenal inner zone antigen as a heme-binding protein. FEBS journal, 272, 5832–5843.
  • H. McNeill, E. Whitworth, G. P. Vinson, and J. P. Hinson. (2005). Distribution of extracellular signal-regulated protein kinases 1 and 2 in the rat adrenal and their activation by angiotensin II. J. Endocr., 187, 149-157.
  • D. Meffre, B. Delespierre, M. Gouézou, P. Leclerc, G. P. Vinson, M. Schumacher, D. G. Stein and R. Guennoun. (2005). The membrane-associated progesterone-binding protein 25-Dx is expressed in brain regions involved in water homeostasis and is up-regulated after traumatic brain injury. J. Neurochem., 93, 1314–1326.
  • J. G. Ferreira, C. Cruz, G. P. Vinson, and D. Pignatelli. (2004). ACTH modulates ERK phosphorylation in the adrenal gland in a time-dependent manner. Endocr Res, 30, 661-6.
  • Raza F.S., Okamoto M., Takemori H. and Vinson G.P. (2005) "Manganese superoxide dismutase activity in the rat adrenal", J Endocr. 184, pp. 77-84.
  • O'Mahony O.A., Barker S., Puddefoot J.R. and Vinson G.P. (2005) "Synthesis and secretion of angiotensin II by the prostate gland in vitro.", Endocrinology 146, pp. 392-398.
  • Meffre D., Delespierre B., Gouézou M., Leclerc P., Vinson G.P., Schumacher M., Stein D.G. and Guennoun R. (2005) "The membrane-associated progesterone-binding protein 25-Dx is expressed in brain regions involved in water homeostasis and is up-regulated after traumatic brain injury.", J. Neurochem. 93, pp. 1314-1326.
  • Ferreira J.G., Cruz C., Vinson G.P. and Pignatelli D. (2004) "ACTH modulates ERK phosphorylation in the adrenal gland in a time-dependent manner.", Endocr Res 30, pp. 661-666.
  • Min L., Takemori H., Nonaka Y., Katoh Y., Doi J., Horike N., Osamu H., Raza F.S., Vinson G.P. and Okamoto M. (2004) "Characterization of the adrenal-specific antigen IZA (Inner Zone Antigen) and its role in the steroidogenesis.", Mol. Cell Endocr. 215, pp. 143-148.
  • Vinson G.P. (2004) "Glomerulosa function and aldosterone synthesis in the rat.", Mol. Cell. Endocr. 217, pp. 59-65.
  • Xiao F., Puddefoot J.R., Barker S. and Vinson G.P. (2004) "Mechanism for aldosterone potentiation of angiotensin II-stimulated rat arterial smooth muscle cell proliferation.", Hypertension 44, pp. 340-345.
  • Vinson G.P. (2003) "Adrenocortical zonation and ACTH.", Microsc Res Tech 61, pp. 227-239.
  • Laskowska M., Vinson G.P., Szumilo J., Laskowska K., Leszczynska-Gorzelak B. and Oleszczuk J. (2003) "Comparative Analysis of the Angiotensin-II Receptor in Placental Vascular Endothelial Cells in Preeclamptic and Normotensive Patients.", Gynecol Obstet Invest 56, pp. 55-60.
  • Labombarda F., Gonzalez S.L., Deniselle M.C., Schumacher M., De Nicola A.F., Vinson G.P. and Guennoun R. (2003) "Effects of injury and progesterone treatment on progesterone receptor and progesterone binding protein 25-Dx expression in the rat spinal cord.", J Neurochem 87, pp. 902-913.
  • Berry M.G., Goode A.W., Puddefoot J.R., Vinson G.P. and Carpenter R. (2003) "Integrin beta1-mediated invasion of human breast cancer cells: an ex vivo assay for invasiveness.", Breast Cancer 10, pp. 214-219.
  • Mahmood T., Djahanbakhch O., Burleigh D.E., Puddefoot J.R., O'Mahony O.A. and Vinson G.P. (2002) "Effect of angiotensin II on ion transport across human Fallopian tube", Reproduction 124, pp. 573-579.
  • Whitworth E.J., Hinson J.P. and Vinson J.P. (2002) "Neuropeptides and adrenocortical proliferation in vitro.", Endocr Res. 28(4), pp. 677-681.
  • Puddefoot J.R., Barker S., Glover H.R., Malouitre S.D. and Vinson G.P. (2002) "Non-competitive steroid inhibition of oestrogen receptor functions.", Int J Cancer. 101, pp. 17-22.
  • Pignatelli D., Ferreira J., Vendeira P., Magalhaes M.C. and Vinson G.P. (2002) "Proliferation of capsular stem cells induced by ACTH in the rat adrenal cortex.", Endocr Res 28, pp. 683-691.
  • Fraser L.R., Pondel M.D. and Vinson G.P. (2001) "Calcitonin, angiotensin II and FPP significantly modulate mouse sperm function.", Mol. Hum. Reprod. 7, pp. 245-253.
  • Raza F.S., Takemori H., Tojo H., Okamoto M. and Vinson G.P. (2001) "Identification of the rat adrenal zona fasciculata/reticularis specific protein, inner zone antigen (IZAg), as the putative membrane progesterone receptor.", Eur. J. Biochem. 268, pp. 2141-2147.
  • Mahmood T., Djahambakhch O., Burleigh D.E., Puddefoot J.R. and Vinson G.P. (2001) "The effect of a cAMP on ion transport in fallopian tube epithelial cells in vitro.", Molecular Human Reproduction 7, pp. 957-961.
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