Dr Brendan Curran
Email: firstname.lastname@example.orgTelephone: +44 (0)20 7882 3013Room Number: Room 5.14, Fogg building
With over 25 years of research experience in studying yeast, a model eukaryotic organism, my current research is focused on the molecular physiology of the yeast Heat Shock Response (HSR).
Heat stress induces a subset of genes that encode protective proteins whenever living cells are exposed to a sub-lethal temperature shock. In 1994 we demonstrated that lipids play a vital role in how cells detect stress thereby successfully challenging the accepted paradigm that heat directly induced proteins to unfold - the latter then triggering the response.
We have published a series of papers since then which demonstrate that lipids are also key players in conferring cross-tolerance between different types of stressing agents. More recently my group has concentrated on the role of Reactive Oxygen Species (ROS) in the HSR and we have published a number of papers implicating ROS as central to the cellular HS response mechanism. We have recently shown that lipids protect anaerobically-grown cells from HS-induced ROS thus relating lipids, ROS and the HSR.
- Browse a list of publications by Brendan Curran