Dr Bob Janes
Email: firstname.lastname@example.orgTelephone: +44 (0)20 7882 8442Room Number: Room G.07, Joseph Priestley Building
Structure-function studies of voltage-gated ion channel toxins
I currently have a number of research projects particularly concerned with polypeptide toxins that selectively block ion channels. These include toxins against voltage-gated calcium, potassium, and sodium channels, as well as neuromuscular and neuronal nicotinic acetylcholine receptors.
Controlled administration of these toxins has been shown to have beneficial therapeutic actions. For example peptomimetic drugs of calcium channel blocking toxins can be used as potential neuroprotectives, assisting in the treatment of stroke patients, as well as being anti-hypertensives, and having positive inotropic and anti-arrhythmic actions on the heart.
We have recently solved the crystal and solution (NMR) structures of alpha-conotoxin SI a blocker of neuromuscular nicotinic acetylcholine receptors.
Over recent years I have developed the technique of SRCD, an exciting extension to the more traditional laboratory-based CD experiments, which will have considerable impact throughout Biological Science research, and Structural Genomics.
Further research interests include aspects of bioinformatics, for example determining the structure, through modelling, and/or function of novel proteins based on their sequence information alone.
In summary, my research into the structure/function relationships of biologically and medically important molecules is aimed towards a better understanding of their three dimensional conformations, which may provide useful information in aiding in the rational design of new drugs.
- Find out more on Dr Janes' research website
Browse a list of publications by Bob Janes