Mechanistic and structural biology
Mechanistic and Structural Biology has traditionally been strong at Queen Mary, and activity in this area has accelerated over the past five years. We have particular research excellence in: (i) photosynthesis and bioenergetics at the molecular and cellular levels; (ii) protein structure and structure/activity relationships in peptides, proteins and enzymes; and (iii) in the synthesis of biologically relevant molecular systems, small molecule catalysts and their biologically inspired analogues. We use a variety of approaches including cloning and over-expression, mechanistic enzymology and structure determination utilising X-ray crystallography and NMR spectroscopy. We have modern and well-equipped facilities for these techniques and also for a variety of other spectroscopic approaches, including circular dichroism, both continuous wave and pulsed EPR and ENDOR, confocal microscopy, Fluorescence Recovery After Photobleaching (FRAP) and fluorescence spectroscopy.
Mechanistic and structural biology members
- John Allen
- Ron Cutler
- Peter Heathcote
- Bob Janes
- Norbert Krauss
- Ewan Main
- Conrad Mullineaux
- Jonathan Nield
- Richard Pickersgill
- Sujith Puthiyaveetil
- Alexander Ruban
- James Sullivan
- John Viles
- Shane Wilkinson
Please see the group members' individual web pages for recent publications and research interests.