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School of Biological and Chemical Sciences

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Molecular genetics of psychiatric disease

Project description

My research group is focused on understanding molecular genetic contributions to the aetiology of psychiatric disease. We use behavioural genetic and developmental analysis of zebrafish lines to explore cellular processes influencing behaviours associated with psychiatric disease and addiction. These behaviours include impulse control, attention, sensory-motor gating and other aspects of executive function such as memory and learning,

The first focus of the project is to understand how mutations that have been shown to be associated with behavioural phenotypes affect the development or functioning of specific neural pathways. For example, antibody staining and in situ hybridization analysis followed by confocal imaging in wild type and mutant lines will be used to test the hypothesis that the gene of interest affects early neuronal development or circuit formation. How environmental conditions impact on development of the pathways i.e. gene:environment interactions, may also be explored.

The second aim is to identify novel mutations influencing behaviours associated with psychiatric disease. Here we aim to screen lines of fish, obtained through collaboration with colleagues in the USA or generated using gene-editing techniques, to identify lines showing heritable behavioural phenotypes.
The translational relevance of results found in zebrafish will be explored by interrogation [e.g. focused SNP analysis] of existing human datasets or datasets obtained through collaboration with colleagues at the Institute of Public Health, QMUL.

The precise details of the project we be determined on discussion with the successful candidate. The successful candidate will need to be able to work independently, as well as working as part of a team. You will receive appropriate training for your research [e.g. behavioural analysis in larval and adult zebrafish, confocal imaging, gene expression analysis and bioinformatics].

Applications are invited from candidates with, or expecting to be awarded, a first class honours degree (or equivalent qualification) or MSc in an area relevant to the project (e.g. biology, psychology, genetics). International students are required to provide evidence of their proficiency in English language skills. Informal enquiries about the project can be made by email to Dr. Caroline Brennan.

Location

Our group is one of several in Biological and Experimental Psychology, of Queen Mary’s School of Biological and Chemical Sciences. Queen Mary is a Russell Group University, a college of the University of London and located in London’s vibrant East End (10 min bicycle ride to Tower Bridge; 10 min walking to Victoria Park).

Funding notes

The successful applicant will either be self-funded or will have secured their own funding through a scholarship. Applicants wishing to apply for PhD funding through Ciência sem Fronteiras, CONACYT or the China Scholarship Council are welcomed, as are those applicants who can self-fund. 
Applicants should be able to demonstrate that they can cover the cost of living expenses and tuition fees for a minimum of 3.5 years. However, the School does offer a limited number of tuition fee only scholarships for excellent applicants and if you wish to apply for these you should discuss this with Dr Brennan. 



Funding through China Scholarship Council

  • Eligibility

Applicants should be Chinese nationals and are required to have at least an upper second class degree and a masters degree in Chemistry, Biochemistry, Material Science or related discipline from a top university anywhere in the world.

International students must provide evidence of proficient English language skills, see our entry requirements page for further information.

  • Applying

Potential candidates should contact the supervisor and submit their CV (including details of two referees) and a cover letter explaining their eligibility and interest in this project.

If you are successful we will give you an offer on the condition that you are given a funding award from the China Scholarship Council. When you have received a conditional offer, apply directly to the China Scholarship Council.

Funding through CONACYT

  • Eligibility

We welcome enquiries from excellent students with a degree in Chemistry, Biochemistry, Material Science or related discipline.

Applicant requirements are listed on the CONACYT foreign scholarship pages.

International students must provide evidence of proficient English language skills, see our entry requirements page for further information.

  • Applying

Potential candidates should contact the supervisor and submit their CV (including details of two referees) and a cover letter explaining their eligibility and interest in this project.

Applications to Queen Mary are accepted all year round but we encourage you to contact the supervisor as soon as possible. If he agrees to take your application further you will be required to submit an online application.

If you are successful we will give you an offer on the condition that you are given a funding award from CONACYT.

When you have received a conditional offer from us, you should apply directly to CONACYT.

Funding through Ciência sem Fronteiras

  • Eligibility

Applicants must be Brazilian nationals and are required to have at least an upper second class degree and a masters degree in Chemistry, Biochemistry, Material Science or related discipline from a top university anywhere in the world.

International students must provide evidence of proficient English language skills, see our entry requirements page for further information.

  • Applying

Potential candidates should contact the supervisor and submit their CV (including details of two referees) and a cover letter explaining their eligibility and interest in this project.

Applications to Queen Mary and Ciência sem Fronteiras are accepted all year round but we encourage you to contact Dr Pluess as soon as possible.

If you are successful we will give you an offer on the condition that you are given a funding award from Ciência sem Fronteiras. When you have received a conditional offer, apply directly to Ciência sem Fronteiras.

Self-funding

If you are interested in self-funding please contact the supervisor to discuss your eligibility for this project.

 

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