GLOSSARY OF TERMS USED IN MEDICINAL CHEMISTRY
(IUPAC Recommendations 1998)

Contents


Quick move to A, B, C, D, E, G, H, I, L, M, N, O, P, Q, R, S, T, X.


Active transport
Address-message concept
ADME
Affinity
Agonist
Allosteric binding sites
Allosteric enzyme
Allosteric regulation
Analog
Antagonist
Antimetabolite
Antisense molecule
Autacoid
Autoreceptor

Bioassay
Bioisostere
Bioprecursor prodrug
Biotransformation

CADD See Computer-assisted drug design.
Carrier-linked prodrug (Carrier prodrug)
Cascade prodrug
Catabolism
Catabolite
Clone
Codon
Coenzyme
Combinatorial library
Combinatorial synthesis
CoMFA See Comparative Molecular Field Analysis
Comparative Molecular Field Analysis (CoMFA)
Computational chemistry
Computer-assisted drug design (CADD)
Congener
Cooperativity

3D-QSAR See Three-dimensional Quantitative Structure-Activity Relationship
De novo design
Disposition See Drug disposition
Distomer
Docking studies
Double-blind study
Double prodrug (or pro-prodrug)
Drug
Drug disposition
Drug latentiation
Drug targeting
Dual action drug

Efficacy
Elimination
Enzyme
Enzyme induction
Enzyme repression
Eudismic ratio
Eutomer

Genome

Hansch analysis
Hapten
Hard drug
Heteroreceptor
Homologue
Hormone
Hydrophilicity
Hydrophobicity

IND
Intrinsic activity
Inverse agonist
Isosteres

Latentiated drug See Drug Latentiation.
Lead discovery
Lead generation
Lead optimization
Lipophilicity

Medicinal chemistry
Metabolism
Metabolite
Me-too drug
Molecular graphics
Molecular modeling
Mutagen
Mutual prodrug

NCE See New Chemical Entity.
NDA
New Chemical Entity.
Non-classical isostere See Bioisostere.
Nucleic acid
Nucleoside
Nucleotide

Oligonucleotide
Oncogene
Orphan drug

Partial agonist
Pattern recognition
Peptidomimetic
Peptoid
Pfeiffer's rule
Pharmacokinetics
Pharmacophore (pharmacophoric pattern)
Pharmacophoric descriptors
Placebo
Potency
Prodrug

QSAR See Quantitative Structure-Activity Relationships
Quantitative Structure-Activity Relationships (QSAR)

Receptor
Receptor mapping

Second messenger
Site-specific delivery
Soft drug
SPC See Structure-property correlations
Structure-activity relationship (SAR)
Structure-based design
Structure-property correlations (SPC)
Systemic

Teratogen
Three-dimensional Quantitative Structure-Activity Relationship (3D-QSAR)
Topliss tree
Transition-state analog

Xenobiotic


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