Creatine Biosynthesis

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© IUBMB 2003

Note: The upper part of the diagram shows mammalian metabolism. The three enzymes shown at the bottom, EC 3.5.4.21, EC 3.5.2.14, and EC 3.5.1.59, are not known to occur in mammals.


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arginine biosynthesis.
EC 2.1.1.2 guanidinoacetate N-methyltransferase
EC 2.1.4.1 glycine amidinotransferase
EC 2.7.3.2 creatine kinase
EC 3.5.1.59 N-carbamoylsarcosine amidase
EC 3.5.2.14 N-methylhydantoinase (ATP-hydrolysing)
EC 3.5.3.3 creatinase
EC 3.5.4.21 creatinine deaminase