EC 7.2.2.22

Reaction: ATP + H₂O + Mn²⁺_{[side 1]} = ADP + phosphate + Mn²⁺_{[side 2]}

Other name(s): Mn(II)-translocating P-type ATPase; Mn²⁺-exporting ATPase; P1B-type ATPase (ambiguous); ctpC (gene name)

Systematic name: ATP phosphohydrolase (P-type, Mn²⁺-exporting)

Comments: A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme, detected in mycobacteria, is a high affinity slow turnover ATPase exporting Mn²⁺.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Padilla-Benavides, T., Long, J.E., Raimunda, D., Sassetti, C.M. and Arguello, J.M. A novel P(1B)-type Mn²⁺-transporting ATPase is required for secreted protein metallation in mycobacteria. J. Biol. Chem. 288 (2013) 11334-11347. [PMID: 23482562]