Reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nω-L-arginino)succinate
For diagram click here.
Other name(s): citrulline—aspartate ligase; argininosuccinate synthetase; arginine succinate synthetase; argininosuccinic acid synthetase; arginosuccinate synthetase
Systematic name: L-citrulline:L-aspartate ligase (AMP-forming)
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9023-58-9
References:
1. Ratner, S. Urea synthesis and metabolism of arginine and citrulline. Adv. Enzymol. Relat. Subj. Biochem. 15 (1954) 319-387.
2. Schuegraf, A., Ratner, S. and Warner, R.C. Free energy changes of the argininosuccinate synthetase reaction and of the hydrolysis of the inner pyrophosphate bond of adenosine triphosphate. J. Biol. Chem. 235 (1960) 3597-3602.