Reaction: β-D-glucose 1-phosphate = β-D-glucose 6-phosphate
For diagram of reaction click here.
Systematic name: β-D-glucose 1,6-phosphomutase
Comments: The enzyme requires Mg2+ and phosphorylation of an aspartate residue at the active site. The enzyme is able to autophosphorylate itself with its substrate β-D-glucose 1-phosphate. Although this is a slow reaction, only a single turnover is required for activation. Once the phosphorylated enzyme is formed, it generates the reaction intermediate β-D-glucose 1,6-bisphosphate, which can be used to phosphorylate the enzyme in subsequent cycles . cf. EC 220.127.116.11, phosphoglucomutase (α-D-glucose-1,6-bisphosphate-dependent).
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 68651-99-0
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2. Ray, W.J., Jr. and Peck, E.J., Jr. Phosphomutases, in Boyer, P.D. (Ed.), The Enzymes, 3rd edn., vol. 6, Academic Press, New York, 1972, pp. 407-477.
3. Lahiri, S.D., Zhang, G., Dunaway-Mariano, D. and Allen, K.N. The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction. Science 299 (2003) 2067-2071. [PMID: 12637673]
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