Reaction: (5Z,13E,15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9α,15-dihydroxy-11-oxoprosta-5,13-dienoate
Other name(s): prostaglandin-H2 Δ-isomerase; prostaglandin-R-prostaglandin D isomerase; PGH-PGD isomerase; prostaglandin endoperoxide Δ-isomerase; prostaglandin D synthetase; (5Z,13E)-(15S)-9a,11a-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
Systematic name: (5Z,13E,15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate Δ-isomerase
Comments: Brings about the opening of the epidioxy bridge. Some enzymes require glutathione.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 65802-85-9
References:
1. Christ-Hazelhof, E. and Nugteren, D.H. Purification and characterisation of prostaglandin endoperoxide Δ-isomerase, a cytoplasmic, glutathione-requiring enzyme. Biochim. Biophys. Acta 572 (1979) 43-51. [PMID: 32914]
2. Shimizu, T., Yamamoto, S. and Hayaishi, O. Purification and properties of prostaglandin D synthetase from rat brain. J. Biol. Chem. 254 (1979) 5222-5228. [PMID: 109431]