Reaction: Catalyses the rearrangement of -S-S- bonds in proteins
Other name(s): S-S rearrangase
Systematic name: protein disulfide-isomerase
Comments: Needs reducing agents or partly reduced enzyme; the reaction depends on sulfhydryl-disulfide interchange.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37318-49-3
References:
1. De Lorenzo, F., Goldberger, R.F., Steers, E., Givol, D. and Anfinsen, C.B. Purification and properties of an enzyme from beef liver which catalyzes sulfhydryl-disulfide interchange in proteins. J. Biol. Chem. 241 (1966) 1562-1567. [PMID: 5946614]
2. Fuchs, S., De Lorenzo, F. and Anfinsen, C.B. Studies on the mechanism of the enzymic catalysis of disulfide interchange in proteins. J. Biol. Chem. 242 (1967) 398-402. [PMID: 6022836]