Reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al
Other Name(s): 11-deoxycorticosterone ketol-isomerase
Systematic name: 11-deoxycorticosterone aldose-ketose-isomerase
Comments: An epimerization at C-20 and C-21 is probably catalysed by the same enzyme.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 75139-73-0
References:
1. Martin, K.O., Oh, S.-W., Lee, H.J. and Monder, C. Studies on 21-3H-labeled corticosteroids: evidence for isomerization of the ketol side chain of 11-deoxycorticosterone by a hamster liver enzyme. Biochemistry 16 (1977) 3803-3809. [PMID: 901753]
2. Monder, C., Martin, K.O. and Bogumil, J. Presence of epimerase activity in hamster liver corticosteroid side chain isomerase. J. Biol. Chem. 255 (1980) 7192-7198. [PMID: 7391077]