IUBMB Enzyme Nomenclature


Accepted name: peptidylamidoglycolate lyase

Reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate

Other name(s): α-hydroxyglycine amidating dealkylase; peptidyl-α-hydroxyglycine α-amidating lyase; HGAD; PGL; PAL; peptidylamidoglycolate peptidylamide-lyase

Systematic name: peptidylamidoglycolate peptidyl-amide-lyase (glyoxylate-forming)

Comments: The enzyme acts on the product of the reaction catalysed by EC peptidylglycine monooxygenase, thus removing a terminal glycine residue and leaving a des-glycine peptide amide.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 131689-50-4


1. Katapodis, A.G., Ping, D. and May, S.W. A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of α-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine α-amidating monooxygenase in peptide amidation. Biochemistry 29 (1990) 6115-6120. [PMID: 2207061]

[EC created 1992]

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