Reaction: (2E,6E)-farnesyl diphosphate = Δ6-protoilludene + diphosphate
For diagram of reaction click here.
Glossary: Δ6-protoilludene = (4aS,7aS,7bR)-3,6,6,7b-tetramethyl-2,4,4a,5,6,7,7a,7b-octahydro-1H-cyclobuta[1,2-e]indene
Other name(s): 6-protoilludene synthase
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, Δ6-protoilludene-forming)
Comments: Isolated from the fungus Armillaria gallica. Δ6-Protoilludene is the first step in the biosynthesis of the melleolides.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:
References:
1. Engels, B., Heinig, U., Grothe, T., Stadler, M. and Jennewein, S. Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides. J. Biol. Chem. 286 (2011) 6871-6878. [PMID: 21148562]