Reaction: Elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar.
Other name(s): heparin-sulfate eliminase; heparitin-sulfate lyase; heparitinase I; heparitinase II
Systematic name: heparin-sulfate lyase
Comments: Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37290-86-1
References:
1. Hovingh, P. and Linker, A. The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria. J. Biol. Chem. 245 (1970) 6170-6175. [PMID: 5484472]