Reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O
For diagram of reaction click here.
Other name(s): D-gluconate dehydratase; D-gluconate hydro-lyase
Systematic name: D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)
Comments: The enzyme shows no activity with D-galactonate [2]. cf. EC 4.2.1.140, gluconate/galactonate dehydratase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37290-75-8
References:
1. Andreesen, J.R. and Gottschalk, G. The occurrence of a modified Entner-Doudoroff pathway in Clostridium aceticum. Arch. Mikrobiol. 69 (1969) 160-170. [PMID: 5383859]
2. Bender, R. and Gottschalk, G. Purification and properties of D-gluconate dehydratase from Clostridium pasteurianum. Eur. J. Biochem. 40 (1973) 309-321. [PMID: 4772682]