Reaction: (2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate
For diagram click here.
Glossary: (+)-citramalate = (2S)-2-hydroxy-2-methylbutanedioate
Other name(s): citramalate pyruvate-lyase; citramalate synthase; citramalic-condensing enzyme; citramalate synthetase; citramalic synthase; (S)-citramalate lyase; (+)-citramalate pyruvate-lyase; citramalate pyruvate lyase; (3S)-citramalate pyruvate-lyase; (2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase
Systematic name: (2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase (acetate-forming)
Comments: The enzyme can be dissociated into components, two of which are identical with EC 220.127.116.11 (citramalate CoA-transferase) and EC 18.104.22.168 (citramalyl-CoA lyase).
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9027-93-4
1. Barker, H.A. Citramalate lyase of Clostridium tetanomorphum. Arch. Mikrobiol. 59 (1967) 4-12. [PMID: 4301387]
2. Dimroth, P., Buckel, W., Loyal, R. and Eggerer, H. Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase. Eur. J. Biochem. 80 (1977) 469-477. [PMID: 923590]