Reaction: GTP + H2O = GDP + phosphate
Systematic name: GTP phosphohydrolase (cell-regulating)
Comments: A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the α-subunit of heterotrimeric G-protein GTPase (EC 22.214.171.124). They are involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:
1. Bourne, H.R., Sanders, D.A. and McCormick, F. The GTPase superfamily: conserved structure and molecular mechanisms. Nature 349 (1991) 117-127. [PMID: 1898771]
2. Hall, A. Small GTP-binding proteins and the regulation of actin cytoskeleton. Annu. Rev. Cell Biol. 10 (1994) 31-54. [PMID: 7888179]
3. Geyer, M. and Wittinghofer, A. GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins. Curr. Opin. Struct. Biol. 7 (1997) 786-792. [PMID: 9434896]
4. Vitale, N., Moss, J. and Vaughan, M. Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1). J. Biol. Chem. 273 (1998) 2553-2560. [PMID: 9446556]