IUBMB Enzyme Nomenclature


Accepted name: Na+/K+-exchanging ATPase

Reaction: ATP + H2O + Na+in + K+out = ADP + phosphate + Na+out + K+in

Systematic name: ATP phosphohydrolase (Na+/K+-exchanging)

Other name: sodium pump; Na+,K+ pump; Na,K-pump; (Na+ + K+)-activated ATPase; (Na+ + K+)-ATPase; Na+,K+-ATPase; Na,K-activated ATPase

Comments: A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Skou, J.C. The influence of some cations on an adenosinetriphosphatase from peripheral nerve. Biochim. Biophys. Acta 23 (1957) 394-401.

2. Post, R.L., Sen, A.K. and Rosenthal, A.S. A phosphorylated intermediate in adenosine triphosphate-dependent sodium and potassium transport across kidney membrane. J. Biol. Chem. 240 (1965) 1437-1445.

3. Skou, J.C. The energy-coupled exchange of Na+ for K+ across the cell membrane. The Na+,K+ pump. FEBS Lett. 268 (1990) 314-324. [PMID: 2166689]

[EC created 1984 as EC, transferred 2000 to EC, modified 2001]

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