IUBMB Enzyme Nomenclature


Accepted name: Na+-transporting two-sector ATPase

Reaction: ATP + H2O + Na+in = ADP + phosphate + Na+out

Systematic name: ATP phosphohydrolase (Na+-transporting)

Other name: ATP synthase; vacuolar-type Na+-ATPase; Na+-translocating ATPase; Na+-translocating F1Fo-ATPase; vacuolar-type Na+-translocating ATPase

Comments: A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. An enzyme found in alkaliphilic bacteria that is similar to EC (H+-transporting two-sector ATPase) where Na+ replaces H+.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Solioz, M. and Davies, K. Operon of vacuolar-type Na+-ATPase of Enterococcus hirae. J. Biol. Chem. 269 (1994) 9453-9459. [PMID: 8144530]

2. Takase, K., Kakinuma, S., Yamato, I., Konishi, K., Igarashi, K. and Kanikuma, Y. Sequencing and characterization of the ntp gene cluster for vacuolar-type Na+-translocating ATPase of Enterococcus hirae. J. Biol. Chem. 269 (1994) 11037-11044. [PMID: 8157629]

3. Rahlfs, S. and Müller, V. Sequence of subunit c of the Na+-translocating F1Fo-ATPase of Acetobacterium woodii: proposal for determinants of Na+ specificity as revealed by sequence comparisons. FEBS Lett. 404 (1997) 269-271. [PMID: 9119076]

[EC created 2000]

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