IUBMB Enzyme Nomenclature


Accepted name: dUTP diphosphatase

Reaction: dUTP + H2O = dUMP + diphosphate

Other name(s): deoxyuridine-triphosphatase; dUTPase; dUTP pyrophosphatase; desoxyuridine 5'-triphosphate nucleotidohydrolase; desoxyuridine 5'-triphosphatase

Systematic name: dUTP nucleotidohydrolase

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37289-34-2


1. Bertani, L.E., Häggmark, A. and Reichard, P. Enzymatic synthesis of deoxyribonucleotides. II. Formation and interconversion of deoxyuridine phosphates. J. Biol. Chem. 238 (1963) 3407-3413.

2. Giroir, L.E. and Deutsch, W.A. Drosophila deoxyuridine triphosphatase. Purification and characterization. J. Biol. Chem. 262 (1987) 130-134. [PMID: 3025197]

3. Greenberg, G.R. and Somerville, R.L. Deoxyuridylate kinase activity and deoxyuridinetriphosphatase in Escherichia coli.Proc. Natl. Acad. Sci. USA 48 (1962) 247-257.

4. Grindey, G.B. and Nichol, C.A. Mammalian deoxyuridine 5'-triphosphate pyrophosphatase. Biochim. Biophys. Acta 240 (1971) 180-183. [PMID: 5105331]

[EC created 1972]

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