EC 3.5.99.15

Reaction: deacetylisoipecoside + H₂O = dopamine + secologanin

For diagram of reaction, click here

Glossary: dopamine = 4-(2-aminoethyl)benzene-1,2-diol

Other name(s): deacetylisoipecoside dopamine-lyase; deacetylisoipecoside dopamine-lyase (secologanin-forming)

Systematic name: deacetylisoipecoside dopamine-hydolase (secologanin-forming)

Comments: The enzyme from the leaves of Alangium lamarckii differs in enantiomeric specificity from EC 3.5.99.16, deacetylipecoside synthase. The product is rapidly converted to demethylisoalangiside.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. DeEknamkul, W., Ounaroon, A., Tanahashi, T., Kutchan, T. and Zenk, M.H. Enzymatic condensation of dopamine and secologanin by cell-free extracts of Alangium lamarckii. Phytochemistry 45 (1997) 477-484.