Reaction: adenine37 in tRNAAla + H2O = hypoxanthine37 in tRNAAla + NH3
Other name(s): ADAT1; Tad1p
Systematic name: tRNAAla(adenine37) aminohydrolase
Comments: The enzyme deaminates adenosine37 to inosine in eukaryotic tRNAAla . tRNA editing is strictly dependent on Mg2+ .
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Maas, S., Gerber, A.P. and Rich, A. Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. Proc. Natl. Acad. Sci. USA 96 (1999) 8895-8900. [PMID: 10430867]
2. Gerber, A., Grosjean, H., Melcher, T. and Keller, W. Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2. EMBO J. 17 (1998) 4780-4789. [PMID: 9707437]
3. Keegan, L.P., Gerber, A.P., Brindle, J., Leemans, R., Gallo, A., Keller, W. and O'Connell, M.A. The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification. Mol. Cell Biol. 20 (2000) 825-833. [PMID: 10629039]