Reaction: (S)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2
For diagram of reaction click here.
Other name(s): ureidoglycolate hydrolase; UAH (gene name)
Systematic name: (S)-ureidoglycolate amidohydrolase (decarboxylating)
Comments: This plant enzyme is involved in the degradation of ureidoglycolate, an intermediate of purine degradation. Not to be confused with EC 22.214.171.124, ureidoglycolate lyase, which releases urea rather than ammonia.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
1. Winkler, R.G., Blevins, D.G. and Randall, D.D. Ureide catabolism in soybeans. III. Ureidoglycolate amidohydrolase and allantoate amidohydrolase are activities of an allantoate degrading enzyme complex. Plant Physiol. 86 (1988) 1084-1088. [PMID: 16666035]
2. Wells, X.E. and Lees, E.M. Ureidoglycolate amidohydrolase from developing French bean fruits (Phaseolus vulgaris [L.].). Arch. Biochem. Biophys. 287 (1991) 151-159. [PMID: 1910298]
3. Werner, A.K., Romeis, T. and Witte, C.P. Ureide catabolism in Arabidopsis thaliana and Escherichia coli. Nat. Chem. Biol. 6 (2010) 19-21. [PMID: 19935661]