IUBMB Enzyme Nomenclature

EC 3.4.24.47

Accepted name: horrilysin

Reaction: Cleavage of only the single bond Ala14Leu in the insulin B chain, Ser12Leu in the A chain, and IleGly, ProAla, and SerTrp in melittin

Other names: Crotalus horridus metalloendopeptidase; hemorrhagic proteinase IV; Crotalus horridus horridus venom hemorrhagic proteinase

Comments: A 56 kDa hemorrhagic endopeptidase from the venom of the timber rattlesnake (Crotalus horridus horridus) that cleaves basement membrane, hide powder and fibrinogen.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 84056-81-5

References:

1. Civello, D.J., Duong, H.L. and Geren, C.R. Isolation and characterization of a hemorrhagic proteinase from timber rattlesnake venom. Biochemistry 22 (1983) 749-755. [PMID: 6340728]

2. Civello, D.J., Moran, J.B. and Geren, C.R. Substrate specificity of a hemorrhagic proteinase from timber rattlesnake venom. Biochemistry 22 (1983) 755-762. [PMID: 6340729]

[EC 3.4.24.47 created 1992]


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