IUBMB Enzyme Nomenclature

EC 3.4.24.43

Accepted name: atroxase

Reaction: Cleavage of His⁵Leu, Ser⁹His, His¹⁰Leu, Ala¹⁴Leu and Tyr¹⁶Leu of insulin B chain

Comments: A nonhemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that cleaves fibrinogen. In peptidase family M12 (astacin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 181186-94-7

References:

1. Willis, T.W. and Tu, A.T. Purification and biochemical characterization of atroxase, a nonhemorrhagic fibrinolytic protease from western diamondback rattlesnake venom. Biochemistry 27 (1988) 4769-4777. [PMID: 3167016]

[EC 3.4.24.43 created 1992]

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