Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Reaction: Broad endopeptidase specificity. Cleaves Glu-Val-Asn-LeuAsp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Other name(s): β-secretase; β-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1)
Comments: Suggested to be the major "β-secretase" responsible for the cleavage of the β-amyloid precursor protein to form the amyloidogenic β-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 158736-49-3
References:
1. Turner, R.T., III, Koelsch, G., Hong, L., CAStenheira, P., Ghosh, A. and Tang, J. Subsite specificity of memapsin 2 (β-secretase): implications for inhibitor design. Biochemistry 40 (2001) 10001-10006. [PMID: 11513577]
2. Hong, L., Turner, R.T., Koelsch, G., Shin, D., Ghosh, A.K. and Tang, J. Crystal structure of memapsin 2 (β-secretase) in complex with an inhibitor OM00-3. Biochemistry 41 (2002) 10963-10967. [PMID: 12206667]