bond in angiotensinogen to generate angiotensin I
Reaction: Cleavage of Leu bond in angiotensinogen to generate angiotensin I
Other names: angiotensin-forming enzyme; angiotensinogenase
Comments: Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family). Formerly EC 3.4.99.19
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 9015-94-5
References:
1. Inagami, T. and Murakami, K. Pure renin. Isolation from hog kidney and characterization. J. Biol. Chem. 252 (1977) 2978-2983. [PMID: 16012]
2. Slater, E.E. Renin. Methods Enzymol. 80 (1981) 427-442. [PMID: 7043197]
3. Inagami, T. Structure and function of renin. J. Hypertension 7 (Suppl. 2) (1989) S3-S8. [PMID: 2785652]
4. Sielecki, A.R., Hayakawa, K., Fujinaga, M., Murphy, M.E.P., Fraser, M., Muir, A.K., Carilli, C.T., Lewicki, J.A., Baxter, J.D. and James, M.N.G. Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 Å resolution. Science 243 (1989) 1346-1351. [PMID: 2493678]