IUBMB Enzyme Nomenclature

EC 3.2.2.26

Accepted name: futalosine hydrolase

Reaction: futalosine + H2O = dehypoxanthine futalosine + hypoxanthine

For diagram of reaction click here.

Glossary: futalosine = 3-(3-((3S,4R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9(6H)-yl)tetrahydrofuran-2-yl)propanoyl)benzoate
dehypoxanthine futalosine = 7-(3-carboxyphenyl)-D-ribo-7-dehydro-5,6-dideoxyheptose

Other name(s): futalosine nucleosidase; MqnB (ambiguous)

Systematic name: futalosine ribohydrolase

Comments: This enzyme, which is specific for futalosine, catalyses the second step of a novel menaquinone biosynthetic pathway that is found in some prokaryotes.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Hiratsuka, T., Furihata, K., Ishikawa, J., Yamashita, H., Itoh, N., Seto, H. and Dairi, T. An alternative menaquinone biosynthetic pathway operating in microorganisms. Science 321 (2008) 1670-1673. [PMID: 18801996]

[EC 3.2.2.26 created 2008]


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