IUBMB Enzyme Nomenclature


Accepted name: mannosyl-oligosaccharide glucosidase

Reaction: Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc3Man9GlcNAc2

Other name(s): Glc3Man9NAc2 oligosaccharide glucosidase; trimming glucosidase I

Systematic name: mannosyl-oligosaccharide glucohydrolase

Comments: Also acts, more slowly, on the corresponding glycolipids and glycopeptides. Involved in the formation of high-mannose and complex glycoproteins.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 78413-07-7


1. Elting, J.J., Chen, W.W. and Lennarz, J. Characterization of a glucosidase involved in an initial step in the processing of oligosaccharide chains. J. Biol. Chem. 255 (1980) 2325-2331. [PMID: 7358674]

2. Grinna, L.S. and Robbins, P.W. Glycoprotein biosynthesis. Rat liver microsomal glucosidases which process oligosaccharides. J. Biol. Chem. 254 (1979) 8814-8818. [PMID: 479161]

3 Kilker, R.D., Saunier, B., Tkacz, J.S. and Herscovics, A. Partial purification from Saccharomyces cerevisiae of a soluble glucosidase which removes the terminal glucose from the oligosaccharide Glc3Man9GlcNAc2. J. Biol. Chem. 256 (1981) 5299-5603. [PMID: 7014569]

4. Grinna, L.S. and Robbins, P.W. Substrate specificities of rat liver microsomal glucosidases which process glycoproteins. J. Biol. Chem. 255 (1980) 2255-2258. [PMID: 7358666]

5. Mark, M.J. and Kornfeld, S. Partial purification and characterization of the glucosidases involved in the processing of asparagine-linked oligosaccharides. Arch. Biochem. Biophys. 199 (1980) 249-258. [PMID: 7356331]

[EC created 1984]

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