Reaction: [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + H2O = [CysO sulfur-carrier protein]-Gly-NH-CH2-COOH + L-cysteine
Other name(s): mec (gene name)
Systematic name: [CysO sulfur-carrier protein]-S-L-cysteine sulfohydrolase
Comments: Requires Zn2+. The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in an L-cysteine biosynthesis pathway. It acts on the product of EC 2.5.1.113, [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Burns, K.E., Baumgart, S., Dorrestein, P.C., Zhai, H., McLafferty, F.W. and Begley, T.P. Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. J. Am. Chem. Soc. 127 (2005) 11602-11603. [PMID: 16104727]