IUBMB Enzyme Nomenclature

EC 3.1.22.5

Accepted name: deoxyribonuclease X

Reaction: Endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes

Other name(s): Escherichia coli endodeoxyribonuclease; Escherichia coli endodeoxyribonuclease X

Comments: Preference for supercoiled DNA; little activity on linear double-stranded DNA. Inhibited by single-stranded DNA, ATP and AMP.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 97002-82-9

References:

1. Ghosh, S. and DasGupta, U. Studies with endonuclease X: a new deoxyendonuclease of E. coli that preferentially cleaves supercoiled plasmid DNA. Curr. Trends Life Sci. 12 (1984) 79-88.

[EC 3.1.22.5 created 1992]


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