IUBMB Enzyme Nomenclature


Accepted name: 3-mercaptopyruvate sulfurtransferase

Reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate

Other names: β-mercaptopyruvate sulfurtransferase

Systematic name: 3-mercaptopyruvate:cyanide sulfurtransferase

Comments: Sulfite, sulfinates, mercaptoethanol and mercaptopyruvate can also act as acceptors. The bacterial enzyme is a zinc protein.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9026-05-5


1. Fiedler, H. and Wood, J.L. Specificity studies on the β-mercaptopyruvate-cyanide transsulfuration system. J. Biol. Chem. 222 (1956) 387-397.

2. Hylin, J.W. and Wood, J.L. Enzymatic formation of polysulfides from mercaptopyruvate. J. Biol. Chem. 234 (1959) 2141-2144.

3. Sörbo, B.H. Enzymic transfer of sulfur from mercaptopyruvate to sulfite or sulfinates. Biochem. Biophys. Acta 24 (1957) 324-329.

4. Vachek, H. and Wood, J.L. Purification and properties of mercaptopyruvate sulfur transferase of Escherichia coli. Biochim. Biophys. Acta 258 (1972) 133-146. [PMID: 4550801]

5. van den Hamer, C.J.A., Morell, A.G. and Scheinberg, H.I. A study of the copper content of β-mercaptopyruvate trans-sulfurase. J. Biol. Chem. 242 (1967) 2514-2516. [PMID: 6026243]

[EC created 1961]

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