IUBMB Enzyme Nomenclature

EC 2.7.1.52

Accepted name: fucokinase

Reaction: ATP + L-fucose = ADP + β-L-fucose 1-phosphate

For diagram click here.

Other name(s): fucokinase (phosphorylating); fucose kinase; L-fucose kinase; L-fucokinase; ATP:6-deoxy-L-galactose 1-phosphotransferase; ATP:L-fucose 1-phosphotransferase

Systematic name: ATP:β-L-fucose 1-phosphotransferase

Comments: Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37278-00-5

References:

1. Ishihara, H., Massaro, D.J. and Heath, E.C. The metabolism of L-fucose. 3. The enzymatic synthesis of β-L-fucose 1-phosphate. J. Biol. Chem. 243 (1968) 1103-1109. [PMID: 5646161]

2. Butler, W. and Serif, G.S. Fucokinase, its anomeric specificity and mechanism of phosphate group transfer. Biochim. Biophys. Acta 829 (1985) 238-243. [PMID: 2986701]

3. Park, S.H., Pastuszak, I., Drake, R. and Elbein, A.D. Purification to apparent homogeneity and properties of pig kidney L-fucose kinase. J. Biol. Chem. 273 (1998) 5685-5691. [PMID: 9488699]

[EC 2.7.1.52 created 1972, modified 2004]


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