IUBMB Enzyme Nomenclature

EC 2.4.2.3

Accepted name: uridine phosphorylase

Reaction: uridine + phosphate = uracil + α-D-ribose 1-phosphate

Other name(s): pyrimidine phosphorylase; UrdPase; UPH; UPase

Systematic name: uridine:phosphate α-D-ribosyltransferase

Comments: The enzyme participates the the pathways of pyrimidine ribonucleosides degradation and salvage. The mammalian enzyme also accepts 2'-deoxyuridine.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9030-22-2

References:

1. Canellakis, E.S. Pyrimidine metabolism. II. Enzymatic pathways of uracil anabolism. J. Biol. Chem. 227 (1957) 329-338.

2. Paege, L.M. and Schlenk, F. Bacterial uracil riboside phosphorylase. Arch. Biochem. Biophys. 40 (1952) 42-49.

3. Pontis, H., Degerstedt, G. and Reichard, P. Uridine and deoxyuridine phosphorylases from Ehrlich ascites tumor. Biochim. Biophys. Acta 51 (1961) 138-147.

4. Pontis, H., Degerstedt, G. and Reichard, P. Uridine and deoxyuridine phosphorylases from Ehrlich ascites tumor. Biochim. Biophys. Acta 51 (1961) 138-147. [PMID: 13737038]

5. Watanabe, S. and Uchida, T. Cloning and expression of human uridine phosphorylase. Biochem. Biophys. Res. Commun. 216 (1995) 265-272. [PMID: 7488099]

6. Liu, M., Cao, D., Russell, R., Handschumacher, R.E. and Pizzorno, G. Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors. Cancer Res. 58 (1998) 5418-5424. [PMID: 9850074]

[EC 2.4.2.3 created 1961]


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