IUBMB Enzyme Nomenclature


Accepted name: γ-glutamylcyclotransferase

Reaction: (γ-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid

Other name(s): γ-glutamyl-amino acid cyclotransferase; γ-L-glutamylcyclotransferase; L-glutamic cyclase; (5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)

Systematic name: (γ-L-glutamyl)-L-amino-acid γ-glutamyltransferase (cyclizing)

Comments: The enzyme acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9045-44-7


1. Bodnaryk, R.P. and McGirr, L. Purification, properties and function of a unique γ-glutamyl cyclotransferase from the housefly, Musca domestica L. Biochim. Biophys. Acta 315 (1973) 352-362.

2. Orlowski, M., Richman, P.G. and Meister, A. Isolation and properties of γ-L-glutamylcyclotransferase from human brain. Biochemistry 8 (1969) 1048-1055. [PMID: 5781001]

[EC created 1972]

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