IUBMB Enzyme Nomenclature


Accepted name: histone-lysine N-methyltransferase

Reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine

Other name(s): protein methylase III; protein methylase 3; protein (lysine) methyltransferase; protein methyltransferase II; protein-lysine N-methyltransferase; histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase

Systematic name: S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase

Comments: One of a group of enzymes methylating proteins; see also EC [cytochrome-c]-lysine N-methyltransferase and EC calmodulin-lysine N-methyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9055-08-7


1. Paik, W.K. and Kim, S. Solubilization and partial purification of protein methylase 3 from calf thymus nuclei. J. Biol. Chem. 245 (1970) 6010-6015. [PMID: 5484460]

2. Venkatesan, M. and McManus, I.R. Partial purification and characterization of a protein lysine methyltransferase from plasmodia of Physarum polycephalum. Biochemistry 18 (1979) 5365-5371. [PMID: 391266]

[EC created 1976, modified 1982, modified 1983]

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