Reaction: S-adenosyl-L-methionine + 3-amino-2,4-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-amino-2-hydroxy-4-methoxybenzoate
For diagram of reaction, click here
Glossary: cremeomycin = 6-carboxy-2-diazonio-3-methoxyphenolate
Other name(s): creN (gene name)
Systematic name: S-adenosyl-L-methionine:3-amino-4-hydroxybenzoate 4-O-methyltransferase
Comments: The enzyme, characterized from the bacterium Streptomyces cremeus, is involved in cremeomycin biosynthesis.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Waldman, A.J., Pechersky, Y., Wang, P., Wang, J.X. and Balskus, E.P. The cremeomycin biosynthetic gene cluster encodes a pathway for diazo formation. Chembiochem 16 (2015) 2172-2175. [PMID: 26278892]