IUBMB Enzyme Nomenclature

EC 1.5.99.6

Accepted name: spermidine dehydrogenase

Reaction: spermidine + acceptor + H2O = propane-1,3-diamine + 4-aminobutanal + reduced acceptor

Glossary: spermidine

Other name(s): spermidine:(acceptor) oxidoreductase

Systematic name: spermidine:acceptor oxidoreductase

Comments: A flavohemoprotein (FAD). Ferricyanide, 2,6-dichloroindophenol and cytochrome c can act as acceptor. 4-Aminobutanal condenses non-enzymically to 1-pyrroline.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9076-64-6

References:

1. Tabor, C.W. and Kellogg, P.D. Identification of flavin adenine dinucleotide and heme in a homogeneous spermidine dehydrogenase from Serratia marcescens. J. Biol. Chem. 245 (1970) 5424-5433.

2. Tabor, H. and Tabor, C.W. Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. IIE2a Speridine dehydrogenase. Adv. Enzymol. Relat. Areas Mol. Biol. 36 (1972) 225-226.

[EC 1.5.99.6 created 1976]


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