IUBMB Enzyme Nomenclature

EC 1.4.9.2

Accepted name: aralkylamine dehydrogenase (azurin)

Reaction: ArCH2NH2 + H2O + 2 azurin = ArCHO + NH3 + 2 reduced azurin

Glossary: azurin = an electron-transfer protein containing a type-1 copper site

Other name(s): aromatic amine dehydrogenase; arylamine dehydrogenase; tyramine dehydrogenase; aralkylamine:(acceptor) oxidoreductase (deaminating)

Systematic name: aralkylamine:azurin oxidoreductase (deaminating)

Comments: Phenazine methosulfate can act as acceptor. Acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:

References:

1. Iwaki, M., Yagi, T., Horiike, K., Saeki, Y., Ushijima, T. and Nozaki, M. Crystallization and properties of aromatic amine dehydrogenase from Pseudomonas sp. Arch. Biochem. Biophys. 220 (1983) 253-262. [PMID: 6830237]

2. Hyun, Y.L. and Davidson, V.L. Electron transfer reactions between aromatic amine dehydrogenase and azurin. Biochemistry 34 (1995) 12249-12254. [PMID: 7547967]

3. Hyun, Y.L., Zhu, Z. and Davidson, V.L. Gated and ungated electron transfer reactions from aromatic amine dehydrogenase to azurin. J. Biol. Chem. 274 (1999) 29081-29086. [PMID: 10506161]

4. Davidson, V.L. Electron transfer in quinoproteins. Arch. Biochem. Biophys. 428 (2004) 32-40. [PMID: 15234267]

5. Sukumar, N., Chen, Z.W., Ferrari, D., Merli, A., Rossi, G.L., Bellamy, H.D., Chistoserdov, A., Davidson, V.L. and Mathews, F.S. Crystal structure of an electron transfer complex between aromatic amine dehydrogenase and azurin from Alcaligenes faecalis. Biochemistry 45 (2006) 13500-13510. [PMID: 17087503]

[EC 1.4.9.2 created 1986 as EC 1.4.99.4, transferred 2011 to 1.4.9.2]


Return to EC 1.4.9 home page
Return to EC 1.4 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page