IUBMB Enzyme Nomenclature

EC 1.3.99.32

Accepted name: glutaryl-CoA dehydrogenase (non-decarboxylating)

Reaction: glutaryl-CoA + acceptor = (E)-glutaconyl-CoA + reduced acceptor

Glossary: (E)-glutaconyl-CoA = (2E)-4-carboxybut-2-enoyl-CoA

Other name(s): GDHDes; nondecarboxylating glutaryl-coenzyme A dehydrogenase; nondecarboxylating glutaconyl-coenzyme A-forming GDH

Systematic name: glutaryl-CoA:acceptor 2,3-oxidoreductase (non-decarboxylating)

Comments: The enzyme contains FAD. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (EC 1.3.8.6), and a nondecarboxylating enzyme (this entry). The two enzymes cause different structural changes around the glutaconyl carboxylate group, primarily due to the presence of either a tyrosine or a valine residue, respectively, at the active site.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Wischgoll, S., Taubert, M., Peters, F., Jehmlich, N., von Bergen, M. and Boll, M. Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria. J. Bacteriol. 191 (2009) 4401-4409. [PMID: 19395484]

2. Wischgoll, S., Demmer, U., Warkentin, E., Gunther, R., Boll, M. and Ermler, U. Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme A dehydrogenases. Biochemistry 49 (2010) 5350-5357. [PMID: 20486657]

[EC 1.3.99.32 created 2012, modified 2013]


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