Reaction: ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3β-ol + NADPH + H+
For diagram click here.
Other names: sterol Δ24(28)-methylene reductase; sterol Δ24(28)-reductase
Systematic name: ergosterol:NADP+ Δ24(241)-oxidoreductase
Comments: Acts on a range of steroids with a 24(241)-double bond.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
References:
1. Neal, W.D. and Parks, L.W. Sterol 24(28) methylene reductase in Saccharomyces cerevisiae. J. Bacteriol. 129 (1977) 1375-1378. [PMID: 14922]
2. Zweytick, D., Hrastnik, C., Kohlwein. S.D. and Daum, G. Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast Saccharomyces cerevisiae. FEBS Lett. 470 (2000) 83-87. [PMID: 10722850]