Reaction: (S)-dihydroorotate + NADP+ = orotate + NADPH + H+
Other name(s): orotate reductase; dihydro-orotic dehydrogenase; L-5,6-dihydro-orotate:NAD+ oxidoreductase; orotate reductase (NADPH)
Systematic name: (S)-dihydroorotate:NADP+ oxidoreductase
Comments: Binds FMN and FAD . Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 18.104.22.168) or NAD+ (EC 22.214.171.124) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 126.96.36.199) uses quinone as electron acceptor .
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37255-27-9
1. Taylor, W.H., Taylor, M.L. and Eames, D.F. Two functionally different dihydroorotic dehydrogenases in bacteria. J. Bacteriol. 91 (1966) 2251-2256. [PMID: 4380263]
2. Udaka, S. and Vennesland, B. Properties of triphosphopyridine nucleotide-linked dihydroorotic dehydrogenase. J. Biol. Chem. 237 (1962) 2018-2024. [PMID: 13923427]